Tirzepatide: the dual GIP/GLP-1 agonist
How engaging two incretin pathways at once set tirzepatide apart, and what researchers study it for.
Blog
Working notes from the lab. Peptide chemistry, reconstitution and storage, certificates of analysis, GLP-1 analogues, and the science behind each compound in the catalogue.
All publications
41 articles
How engaging two incretin pathways at once set tirzepatide apart, and what researchers study it for.
How amino-acid substitutions, fatty-acid chains and added size extend a peptide's half-life, and why it matters in research.
An amylin analogue from a different hormone family, studied alongside GLP-1 analogues in metabolic research models.
The single-pathway GLP-1 analogue that turned an incretin hormone into one of the most studied molecules in metabolic research.
Semaglutide, tirzepatide, and retatrutide — three GLP-1 analogues, each a step further into multi-receptor metabolic research.
How GLP-1 regulates appetite, body weight, and metabolism, and why analogues like semaglutide and tirzepatide became central to obesity research.
GLP-1, GIP and glucagon receptors explained — the framework behind single, dual and triple agonists in metabolic research.
A stabilised analogue of GHRH, studied for how it engages the pituitary at the natural starting point of the growth-hormone axis.
A GHRH analogue engineered to last far longer than the natural hormone, and why that extended duration matters in research.
A selective GHRP studied for engaging the growth-hormone secretagogue receptor with comparatively little effect on other pathways.
GHRH analogues and GHRPs both prompt the pituitary — through two different receptors. Here is how the two families differ.
NAD+, SS-31 and MOTS-c are three very different molecules united by one research theme: how they relate to the cell's energy compartments.
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome itself — an unusual origin studied in cellular metabolism research.
A small peptide studied for its unusual ability to concentrate inside the mitochondria and interact with cardiolipin.
Why NAD+ sits at the centre of cellular energy research, and what its decline is studied to reveal.
Semax is a synthetic peptide from an ACTH fragment, studied in preclinical models for cognition and neuroprotection.
Selank is a tuftsin-derived synthetic peptide studied in preclinical models for anxiety-related and stress pathways.
A researcher's guide to the five melanocortin receptors, MC1R to MC5R, and why subtype selectivity drives so much peptide work.
A synthetic analogue used to study the melanocortin receptor family and the varied biology it controls.
The GLOW UP kit is a coordinated cosmetic-research stack that keeps each peptide separate for controlled study.
Super GLOW is a multi-peptide research blend studied for its role in skin, collagen, and connective-tissue models.
A naturally occurring tripeptide with a strong affinity for copper ions, studied for collagen synthesis, antioxidant defense, and broad gene-expression effects.
How researchers study peptides in combination — the difference between a blend and a stack, and why formulation and records matter.
BPC-157 and TB-500 are frequently studied together; a blend supplies both peptides in a single lyophilised vial for repair-related research.
A synthetic fragment of Thymosin beta-4, studied for actin regulation, tissue regeneration, and complementary use with BPC-157 in repair protocols.
A synthetic pentadecapeptide derived from a protective protein in human gastric juice, studied for tissue repair, gut protection, and systemic healing.
A concise glossary of the terms researchers meet most often when working with peptides — from lyophilised to in vivo.
Certificates of analysis, third-party testing, cold-chain shipping — the concrete signals that separate a serious supplier from the rest.
Good practice for the researcher: how to keep a peptide stable, sterile and reliable from delivery to the bench.
The cold chain keeps temperature-sensitive peptides within a controlled range from lab to bench — how they should be shipped, received and stored.
Hydrolysis, oxidation, aggregation, contamination — why research peptides degrade, and the handling habits that slow each pathway down.
What U-100 insulin syringes measure, how to read units as volume, and why they suit small-volume peptide research.
How to reconstitute a peptide correctly, how much bacteriostatic water to add, how to draw a dose, and how to store the result. The full method, end to end.
Freeze-drying keeps fragile peptides stable for storage and shipping — a look at what lyophilisation is and why research peptides arrive as powder.
Bacteriostatic water is the preservative-containing diluent used to reconstitute lyophilised peptides — here is what it is and why it matters.
A field-by-field guide to the peptide spec sheet: molecular formula, molar mass, purity, sequence and net peptide content.
What a COA actually contains, how to verify the lab that issued it, and why it is the single most important document accompanying any research peptide.
How HPLC and mass spectrometry work together to measure a research peptide's purity — and why one technique is never enough.
Solid-phase peptide synthesis, HPLC purification, mass-spectrometry identification, and what a 98%+ purity number actually represents for your protocol.
'Research grade' is a statement about intended use and documentation — not a synonym for low quality. Here is what it really means.
A short primer on what peptides are, how they differ from proteins, how they are produced, and why they sit at the center of so much modern research.