SS-31 (Elamipretide): a mitochondria-targeting peptide

SS-31, also known as elamipretide, is a short synthetic peptide that has drawn attention for a specific reason: it is studied for its ability to concentrate inside the mitochondria, the cell's energy compartments, rather than acting on surface receptors like most peptides.

What makes SS-31 distinctive

Most peptides in this catalogue work by binding receptors on the outside of a cell. SS-31 is different. In the research literature it is described as targeting the inner mitochondrial membrane, where it interacts with a lipid called cardiolipin. Cardiolipin is essential to the machinery that produces cellular energy, which is why a molecule that reaches it is of interest to researchers studying mitochondrial function.

Why researchers study it

Because mitochondrial dysfunction is a theme across many areas of research — from energy metabolism to cellular ageing — a peptide that localises to the mitochondria gives researchers a specific tool to study these systems in laboratory models.

Handling

SS-31 is supplied as a lyophilised powder and reconstituted with bacteriostatic water before use. Its small size makes it straightforward to work with; our reconstitution guide covers the standard method.

Quality you can verify

Every SS-31 batch ships with a certificate of analysis issued within six months of sale, so identity and purity are documented before the vial reaches the bench.